Table 1.
The list of most studied senotherapeutic molecules.
| Substance | Mechanism of action | References |
|---|---|---|
| Senolytics – eliminate senescent cells | ||
| Dasatinib | Tyrosine kinase inhibitor | 84 |
| Quercetin | Targets BCL-2 family Regulates NF-kß and P13K/AKT/mTOR Induces HIF-1a |
85 |
| Navitoclax (ABT-263) and ABT-737 | Targets BCL-2, BCL-x(L), BCL-w | 86 |
| Fisetin | Inhibits PI3K/Akt/mTOR, MAPK, NF-κB, and ERK-MYC Targets BCL-2 |
87-90 |
| FOXO4-DRI peptide | Disrupts the p53-FOXO4 interaction | 91,92 |
| Senomorphics - inhibit SASP | ||
| Metformin | Targets NF-κB and Dicer | 93,94 |
| Rapamycin | mTOR inhibitor | 95 |
| Ruxolitinib | Targets JAK (Janus kinase) pathway | 96 |