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. 2022 Oct 3;11:e79128. doi: 10.7554/eLife.79128

Figure 7. MSH6 309 phosphorylation is important for cellular localization.

Figure 7.

(a,b) MEF S6K -/- cells transfected with either Flag-MSH6 WT, MSH6 309 A or MSH6 309D were UV irradiated and fixed 2 hours later. Cells were stained using anti-Flag antibody and DAPI. Fluorescence was quantitated using NIS-element AR software. (c) Diagram depicting S6K1 entrance to the nucleus in response to DNA damaging agents. S6K1 phosphorylation of Cdk1 and MSH6 causes G2/M cell cycle arrest and affects DNA damage repair mechanisms.