Figure 5.

Linear regression analysis of mitochondrial membrane potential, oxygen consumption, and ATP bioavailability with percent relaxation to norepinephrine and intraluminal flow. Mitochondrial membrane potential (JC-1) significantly predicted percent relaxation to norepinephrine [overall regression R² = 0.193, F(1,22) = 5.015, P = 0.036; β = 16.018, P = 0.036; A] and intraluminal flow [overall regression R² = 0.575, F(1,20) = 27.009, P < 0.001; β = 32.293, P < 0.001; D]. Oxygen consumption did not significantly predict percent relaxation to norepinephrine [overall regression R² = 0.00078, F(1,21) = 0.0163, P = 0.9; B] or intraluminal flow [overall regression R² = 0.0122, F(1,20) = 0.246, P = 0.625; E]. Baseline ATP levels nearly significantly predicted relaxation to norepinephrine [overall regression R² = 0.161, F(1,21) = 4.025, P = 0.058; C], but not intraluminal flow-mediated dilation [overall regression R² = 0.0938, F(1,20) = 2.069, P = 0.166; F]. Significance defined as P < 0.05 with linear regression analysis.