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. 2022 Aug 26;323(4):H749–H762. doi: 10.1152/ajpheart.00311.2022

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Figure 6. — Inhibition of fission or fusion on dilation to norepinephrine in YC, OC, and OSVF microvessels. Aging attenuated dilation to norepinephrine, reversed by SVF therapy (A). MYLS22 inhibition of fusion significantly attenuated YC dilation to norepinephrine (B). Inhibition of fission with MDIVI nearly significantly improved OC dilation to norepinephrine at early doses (C). Fusion inhibition significantly abrogated dilation to norepinephrine in OSVF vessels (D). Significance defined as P < 0.05 *[YC vs. OC (A), YC vs. MYLS22 (B), and OSVF vs. MYLS22 (D)] and #[OSVF vs OC (A), YC + MYLS22 vs. MDIVI (B), and OSVF + MYLS22 vs. MDIVI (D)] via two-way repeated-measures ANOVA with Bonferroni post hoc analysis. OC, old control; OSVF, old + stromal vascular fraction therapy; YC, young control.