Figure 7.

Inhibition of fission or fusion on dilation to intraluminal flow in YC, OC, and OSVF microvessels. Aging induced flow-mediated constriction, reversed by SVF therapy achieving flow-mediated dilation akin to YC (A). MYLS22 inhibition of fusion significantly attenuated YC dilation to intraluminal flow (B) OC response to flow was not significantly altered by inhibition of fusion or fission, albeit fission inhibition led to brief dilation at lower flow rates (C). Fission inhibition significantly abrogated dilation to flow in OSVF vessels (D). Significance defined as P < 0.05 via two-way repeated-measures ANOVA with Bonferroni post hoc analysis. OC, old control; OSVF, old + stromal vascular fraction therapy; YC, young control.