Figure 8.
Effects of aging and SVF therapy on mitochondrial function and vasodilation. Illustration summarizes RNA sequencing data, and isolated vessel experimental results in the context of the ETC/oxidative phosphorylation, mitochondrial fission, fusion, mitophagy, and antioxidant/prooxidant enzyme balance and their influences on β1AR-mediated and flow-mediated dilation. Genes were included with significance as P < 0.1. Green arrow indicates activating whereas red line indicates inhibitory action. Note, antioxidant/prooxidant enzyme list and contributions of ROS/NO on β1AR and FMD summarize results from our preceding study (9). Image created with BioRender.com and published with permission. ROS, reactive oxygen species; SVF, stromal vascular fraction.