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. 2022 Aug 22;323(4):C1044–C1051. doi: 10.1152/ajpcell.00047.2022

Figure 3.

Figure 3.

FXYD3 facilitates ion transport across human airway epithelia. A: a representative short-circuit current (Isc) experiment. B: summary data for amiloride-sensitive Isc. Control = 29.75 ± 20.66, FXYD3 siRNA = 21.35 ± 13.10; means ± SD. C: summary data for DIDS-sensitive Isc. Control = 0.65 ± 1.10, FXYD3 siRNA = 0.84 ± 1.21; means ± SD. D: summary data for forskolin and IBMX-sensitive Isc. Control = 3.40 ± 3.00, FXYD3 siRNA = 3.40 ± 3.66; means ± SD. E: summary data for CFTRinh-172-sensitive Isc. Control = 12.53 ± 5.22, FXYD3 siRNA = 10.87 ± 5.36; means ± SD. All compounds were added to the apical chamber, except for forskolin/IBMX, which was bilaterally added. For all summary data, each dot represents the average of technical replicates from 1 human donor (n = 9 donors) and error bars represent the standard error of the mean. P values were calculated using a paired Student’s t test. DIDS, 4,4’-diisothiocyano-2,2’-stilbenedisulfonic acid; IBMX, 3-isobutyl-1-methylxanthine; Isc, short-circuit current; SD, standard deviation.