Table 3.
KEGG pathways enriched in DEGs from the livers of male OB-offspring
| Pathway | Input No. | Total No. | P Value |
|---|---|---|---|
| Metabolic pathways | 91 | 1494 | 1.71e-25 |
| Cell cycle | 18 | 123 | 2.53e-10 |
| Antigen processing and presentation | 15 | 91 | 2.84e-09 |
| Drug metabolism—other enzymes | 12 | 87 | 8.34e-07 |
| Fatty acid metabolism | 9 | 61 | 1.92e-05 |
| Cholesterol metabolism | 8 | 49 | 3.55e-05 |
| PPAR signaling pathway | 10 | 87 | 3.61e-05 |
| MAPK signaling pathway | 17 | 294 | 9.87e-05 |
| AMPK signaling pathway | 11 | 126 | 1.17e-04 |
| Hippo signaling pathway | 12 | 154 | 1.33e-04 |
| Peroxisome | 9 | 84 | 1.65e-04 |
| Cellular senescence | 13 | 186 | 1.69e-04 |
| Retinol metabolism | 9 | 91 | 2.77e-04 |
| Carbon metabolism | 10 | 121 | 3.89e-04 |
| Pyruvate metabolism | 6 | 38 | 5.49e-04 |
| Tight junction | 11 | 167 | 9.61e-04 |
| Glutathione metabolism | 7 | 64 | 1.00e-03 |
| Steroid hormone biosynthesis | 8 | 89 | 1.13e-03 |
| TGF-β signaling pathway | 8 | 95 | 1.60e-03 |
| Fructose and mannose metabolism | 5 | 35 | 2.65e-03 |
| Protein processing in endoplasmic reticulum | 10 | 163 | 2.73e-03 |
| Purine metabolism | 9 | 136 | 3.09e-03 |
| Pyrimidine metabolism | 6 | 58 | 3.25e-03 |
| PI3K-Akt signaling pathway | 15 | 358 | 4.90e-03 |
| Endocytosis | 12 | 270 | 8.70e-03 |
| Linoleic acid metabolism | 5 | 50 | 8.83e-03 |
| Cell adhesion molecules (CAMs) | 9 | 171 | 1.05e-02 |
| Pentose phosphate pathway | 4 | 32 | 1.15e-02 |
| ECM-receptor interaction | 6 | 86 | 1.49e-02 |
| Lysosome | 7 | 124 | 1.97e-02 |
| Glycolysis/Gluconeogenesis | 5 | 67 | 2.26e-02 |
| p53 signaling pathway | 5 | 71 | 2.72e-02 |
| Glucagon signaling pathway | 6 | 105 | 3.09e-02 |
| Ribosome | 8 | 175 | 3.15e-02 |
| Tryptophan metabolism | 4 | 48 | 3.38e-02 |
All significant pathways are presented with the number of differentially expressed genes (DEGs) (Input No.; Gene IDs for each pathway can be found in Supplemental Data) in each pathway’s complete annotated gene number (Total No.). Pathways were filtered by redundancy and only pathways with unique genes are presented. OB, obese; PPAR, peroxisome proliferator-activated receptor. P value is corrected for multiple testing with Benjamini–Hochberg.