Table 5.
Overlapping pathways in the livers of male and female offspring
| Pathway | Genes in males | Genes in females |
|---|---|---|
| Tryptophan metabolism | Kyat, Kynu, Acmsd, Inmt | Kyat1, Acat2, Acmsd, Inmt |
| Fatty acid metabolism | Acox1, Acaca, Acsl3, Scd1, Elovl6, Acat2, Fasn, Scd3, Fads1 | Fads1, Acsl3, Acsl4 |
| PPAR signaling pathway | Cyp7a1, Acsl3, Lpl, Acsl4, Angptl4, Sorbs1, Plin4, Plin5, Apoa2 | Acox1, Acsl3, Cyp4a12b, Scd1, Angptl4, Fabp5, Scd3, Plin4, Cyp7a1, Apoa2 |
| MAPK signaling pathway | Stmn1, Sos1, Hspa8, Map3k5, Vegfa, Dusp16, Irak4 | Igf2, Hspa2, Stmn1, Casp3, Rasgrp3, Cacnb3, Erbb3, Hspa8, Ntrk2, Hspa1b, Tgfbr2, Arrb2, Relb, Map2k7, Myc, Fgf21, Klk1b4 |
| Cell cycle | Pcna, Cdkn2c, Mcm6, Mcm5, Mcm4, Mcm3, Mcm2, Abl1 | Hspa2, H2-T22, Ctsl, Hspa5, Hspa4, H2-Ab1, Calr, Hspa8, H2-Aa, Psme3, H2-Q2, Hspa1b, Ctss, Gm11127, Gm8909 |
| Protein processing in endoplasmic reticulum | Sel1l, Hspa8, Hsph1, Hspa5, Ubqln1, Bak1, Map3k5 | Hspa2, Sel1l, Pdia4, Hsph1, Hspa5, Calr, Hspa8, Hspa1b, Derl3, Map2k7 |
| Peroxisome | Nudt12, Acsl3, Acsl4, Mpv17l | Pmp22, Mpv17l, Acsl3, Acox1, Pmvk, Acot8, Slc25a17, Hao2, Pex12 |
| Antigen processing and presentation | Tapbp, H2-K1, Hspa8, H2-T22, Hspa5 | Hspa2, H2-T22, Ctsl, Hspa5, Hspa4, H2-Ab1, Calr, Hspa8, H2-Aa, Psme3, H2-Q2, Hspa1b, Ctss, Gm11127, Gm8909 |
| Cholesterol metabolism | Pcsk9, Lpl, Angptl4, Vdac1, Cyp7a1, Apoa2 | Lipc, Abcg5, Sort1, Angptl4, Apoa4, Vdac1, Cyp7a1, Apoa2 |
| Metabolic pathways | Atp5c1, Bhmt, Acsl3, Cyp51, Cdo1, Acsl4, Tymp, Oxct1, Cyp26a1, Galnt4, Mtmr4, Fdft1, Acmsd, Inmt, Dhcr7, Gpx3, Phospho1, Fads1, Sat1, Kynu, Idi1, Hyal1, Nampt, Hmgcr, Kyat1, Cyp2c39, Cyp7a1, Plaat3, Msmo1, Car2, Cyp2j9, Gsta1, Nudt12, Selenoi, Lss, B3gat3, Glo1, Sqle, Cndp2, Dhcr24 | Fdps, Hmgcr, Acsl3, Uox, Pmvk, Nampt, Cyp2c23, Acly, Smox, Ugt2b1, Entpd4b, Ggct, G6pdx, Pigw, Coq7, Ndufab1, Sat1, Acox1, Gstt2, Pde6d, Upp2, Papss2, Impdh1, Atp5j, Smpd3, Glo1, Nmnat1, Cyp2c39, Bhmt, Sc5d, Fasn, Synj2, Prodh, Adh1, Inmt, Uprt, Tk1, Treh, Acot8, Gstm3, Gpd1, Gal3st1, Kyat1, Cyp7a1, Lipc, Plpp2, Mgst1, Lss, Pkm, Scd3, Scd1, Tymp, Cyp26a1, Pde4a, Acmsd, Bdh1, Cyp3a41b, Cyp3a41a, Cyp4a12b, Nmrk1, Hao2, Atp6v0c, Azin2, Gstp1, Hnmt, Pfkfb1, Acss2, Car1, Elovl6, Got1, B4galt7, Ak2, Pgm3, Acat2, Ipmk, Sord, Phospho2, Phospho1, Fads1, Gpam, Acaca, Ndufb9, Acacb, Pnp2, Gmppa, Pfkp, Aldoc, Cyp2c38, Gsta1, Pnpla3, Acy1 |
Abl1, c-abl oncogene 1, non-receptor tyrosine kinase; Acaca, acetyl-Coenzyme A carboxylase alpha; Acat2, acetyl-Coenzyme A acetyltransferase 2; Acmsd, amino carboxymuconate semialdehyde decarboxylase; Acot8, acyl-CoA thioesterase 8; Acox1, acyl-Coenzyme A oxidase 1, palmitoyl; Acsl3, acyl-CoA synthetase long-chain family member 3; Acsl4, acyl-CoA synthetase long-chain family member 4; Angptl4, angiopoietin-like 4; targeted mutation 1, Velocigene; Apoa2, apolipoprotein A-II; Arrb2, arrestin, beta 2; Bak1, BCL2-antagonist/killer 1; Cacnb3, calcium channel, voltage-dependent, beta 3 subunit; Calr, calreticulin; Casp3, caspase 3; Cdkn2c, cyclin dependent kinase inhibitor 2C; Ctsl, cathepsin L; Ctss, cathepsin S; Cyp4a12b, cytochrome P450, family 4, subfamily a, polypeptide 12B; Cyp7a1, cytochrome P450, family 7, subfamily a, polypeptide 1; Dusp16, dual specificity phosphatase 16; Elovl6, ELOVL family member 6, elongation of long chain fatty acids (yeast); Erbb3, erb-b2 receptor tyrosine kinase 3; Fabp5, fatty acid binding protein 5, epidermal; Fads1, fatty acid desaturase 1; Fasn, fatty acid synthase; Fgf21, fibroblast growth factor 21; Gm11127, predicted gene 11127; Gm8909, predicted gene 8909; H2-Aa, histocompatibility 2, class II antigen A, alpha; H2-Ab1, histocompatibility 2, class II antigen A, beta 1; H2-K1, histocompatibility 2, K1, K region; H2-Q2, histocompatibility 2, Q region locus 2; H2-T22, histocompatibility 2, T region locus 22; Hao2, hydroxyacid oxidase 2; Hspa1b, heat shock protein 1B; Hspa2, heat shock protein 2; Hspa4, heat shock protein 4; Hspa5, heat shock protein 5; Hspa8, heat shock protein 8; Hsph1, heat shock 105 kDa/110 kDa protein 1; Igf2, insulin-like growth factor 2; Inmt, indolethylamine N-methyltransferase; Irak4, interleukin-1 receptor-associated kinase 4; Klk1b4, kallikrein 1-related pepidase b4; Kyat1, kynurenine aminotransferase 1; Kynu, Kynureninase; Lpl, lipoprotein lipase; Map2k7, mitogen-activated protein kinase kinase 7; Map3k5, mitogen-activated protein kinase kinase kinase 5; Mcm2, minichromosome maintenance complex component 2; Mcm3, minichromosome maintenance complex component 3; Mcm4, minichromosome maintenance complex component 4; Mcm5, minichromosome maintenance complex component 5; Mcm6, minichromosome maintenance complex component 6; Mpv17l, Mpv17 transgene, kidney disease mutant-like; Myc, myelocytomatosis oncogene; Ntrk2, neurotrophic tyrosine kinase, receptor, type 2; Nudt12, nudix (nucleoside diphosphate linked moiety X)-type motif 12; Pcna, proliferating cell nuclear antigen; Pdia4, protein disulfide isomerase associated 4; Pex12, peroxisomal biogenesis factor 12; Plin4, perilipin 4; Plin5, perilipin 5; PPAR, peroxisome ploliferator-activated receptor; Pmp22, peripheral myelin protein 22; Pmvk, phosphomevalonate kinase; Psme3, proteaseome (prosome, macropain) activator subunit 3 (PA28 gamma, Ki); Rasgrp3, RAS, guanyl releasing protein 3; Relb, oncogene related B; Scd1, stearoyl-coenzyme A desaturase 1; Scd3, stearoyl-coenzyme A desaturase 3; Sel1l, sel-1 suppressor of lin-12-like (C. elegans); Slc25a17, solute carrier family 25 (mitochondrial carrier, peroxisomal membrane protein), member 17; Sorbs1, sorbin and SH3 domain containing 1; Sos1, SOS Ras/Rac guanine nucleotide exchange factor 1; Stmn1, stathmin 1; Tapbp, TAP binding protein; Tgfbr2, transforming growth factor, beta receptor II; Ubqln1, ubiquilin 1; Vegfa, vascular endothelial growth factor A; v-rel, avian reticuloendotheliosis viral.