Table 9.
KEGG pathways enriched in DEGs from the skeletal muscle of female OB-offspring
| Pathway | Input No. | Total No. | P Value |
|---|---|---|---|
| Proteasome | 10 | 46 | 2.36e-07 |
| mTOR signaling pathway | 14 | 155 | 5.96e-06 |
| Endocytosis | 18 | 270 | 9.22e-06 |
| AMPK signaling pathway | 11 | 126 | 1.01e-04 |
| Insulin signaling pathway | 11 | 140 | 2.30e-04 |
| AGE-RAGE signaling pathway in diabetic complications | 9 | 101 | 4.56e-04 |
| Glucagon signaling pathway | 9 | 105 | 5.75e-04 |
| FoxO signaling pathway | 10 | 132 | 6.09e-04 |
| Parathyroid hormone synthesis, secretion and action | 9 | 107 | 6.45e-04 |
| Insulin resistance | 9 | 110 | 7.66e-04 |
| Longevity regulating pathway | 8 | 90 | 1.04e-03 |
| Ribosome | 11 | 175 | 1.17e-03 |
| Metabolic pathways | 43 | 1494 | 1.18e-03 |
| Cellular senescence | 11 | 186 | 1.77e-03 |
| MAPK signaling pathway | 14 | 294 | 2.27e-03 |
| Wnt signaling pathway | 10 | 162 | 2.32e-03 |
| Adipocytokine signaling pathway | 6 | 71 | 6.44e-03 |
| Focal adhesion | 10 | 199 | 8.15e-03 |
| cGMP-PKG signaling pathway | 9 | 173 | 1.04e-02 |
| ErbB signaling pathway | 6 | 84 | 1.25e-02 |
| PPAR signaling pathway | 6 | 87 | 1.42e-02 |
| Protein processing in endoplasmic reticulum | 8 | 163 | 2.10e-02 |
| Relaxin signaling pathway | 7 | 131 | 2.23e-02 |
| Purine metabolism | 7 | 136 | 2.58e-02 |
| HIF-1 signaling pathway | 6 | 114 | 3.57e-02 |
| Phospholipase D signaling pathway | 7 | 149 | 3.57e-02 |
| Oxytocin signaling pathway | 7 | 154 | 4.02e-02 |
| PI3K-Akt signaling pathway | 12 | 358 | 4.17e-02 |
DEGs, differentially expressed genes; HIF-1, hypoxia-inducible factor 1; mTOR, mechanistic target of rapamycin; OB, obese; PPAR, peroxisome proliferator-activated receptor.