Table 3.

Cognitive and Behavioral Assessments

Blast exposure and medical history
Measure	Construct measured/ data collected	Administration method	Time (min)
Demographics	Age, ethnicity, race, education	REDCap survey pre-visit	15
Military history	Military history, rank, time in service (years)		5
Military occupational status	Blast exposure (indirect)		5
Generalized Blast Exposure Value28	Blast exposure	Pre-visit by phone	10
Deployment Risk & Resiliency Inventory, Combat Experiences Scale, modified for STRONG STAR70,71	Combat exposure	REDCap survey pre-visit	3
Medical history	Symptom characteristics, duration, severity, and treatment	In-person visit - interview	10
Brain Injury Screening Questionnaire72	Lifetime TBI exposure	Pre-visit by phone; follow-up in-person	25
Pittsburgh Sleep Quality Index73,74	Sleep quality & disturbances	REDCap survey pre-visit; spouse by-phone	10
STOP BANG75	Obstructive sleep apnea	REDCap survey pre-visit	< 1
Pupillometry Exam	Pupil constriction and dilation		15

Neurocognitive function
Measure	Construct measured/ data collected	Administration method	Time (min)
Automated Neuropsychological Assessment Metrics76	Processing speed, memory, inhibition, and other cognitive processes	In-person, laptop	35
Philips Intellispace Cognition	Memory, verbal processing, working memory, executive functioning, processing speed, visual spatial processing	In-person visit, iPad	45
Grooved Pegboard Test77,78	Fine motor function	In-person visit	5
Delis-Kaplan Executive Function System79,80	Inhibitory control, cognitive flexibility		10
WAIS- Wechsler Adult Intelligence Scale, 4th version, Digit Span and Arithmetic81	Working memory		30
Test of Premorbid Functioning82	Premorbid ability/cognitive reserve		5
Auditory Consonant Trigrams83	Divided attention, working memory		15

Neurobehavioral function, physical symptoms, and quality of life
Measure	Construct measured/ data collected	Administration method	Time (min)
Patient Health Questionnaire-984	Depression	In-person visit	5
Suicidal Behaviors Questionnaire-Revised85	Suicidality		< 1
Neurobehavioral Symptom Inventory86	Post-concussive symptoms		3
Brown-Goodwin Lifetime History of Aggression87	Aggression		60
Glasgow Outcome Scale- Extended88	Global outcome		15
Mild Brain Injury Atypical Symptoms89	Symptom validity/effort		2
Medical Symptom Validity Test90	Symptom validity/effort		15
Frontal Systems Behavior Scale91	Apathy, disinhibition, executive dysfunction	Participant: In-person visit	10
		Spouse: Phone
PTSD Checklist for DSM-592	Post-traumatic stress disorder	REDCap survey pre-visit	3
RAND-3693	Physical functioning, role limitations, energy/fatigue, emotional well-being, social functioning, pain, general health		5
TBI-Quality of Life short forms94	Anger		2
	Anxiety		2
	Emotional & behavioral dyscontrol		2
	Resilience		2
Buss-Perry Aggression Questionnaire95	Aggression		5
World Health Organization Disability Assessment Schedule96	Cognition, mobility, self-care, getting along, life activities, participation		5
Alcohol Use Disorders Identification Test97,98	Alcohol screening		2
Drug Abuse Screening Test99	Drug screening		3
Headache Impact Test-6100	Headaches		3
PROMIS Short forms101	Pain Intensity		7
	Pain Interference

STOP-BANG, Snoring history, Tired during the day, Observed stop breathing while sleep, High blood pressure, BMI more than 35 kg/m², Age more than 50 years, Neck circumference more than 40 cm and male Gender; PTSD, post-traumatic stress disorder; DSM, Diagnostic and Statistical Manual of Mental Disorders; WHO, World Health Organization, PROMIS, Patient-Reported Outcomes Measurement Information System; REDCap, Research Electronic Data Capture.