Table 3.
Summary of the COVID-19 related CSs on selenium.
| Short title / objective / intervention | Primary purpose (Allocation/Type; Status; Phase; Number enrolled; Results; Comparison group; Primary outcome) | NCT number (Sponsor; Location; Start date; Completion date) |
|---|---|---|
| Selenium efficacy among hospitalized COVID-19 patients (Loading dose of selenious acid infusion (2000 µg) on day 1, and maintenance dose (1000 µg per day) for 2–14 days along with standard care) |
Treatment (Randomized; Not yet recruiting; 2; 100; Not available; Standard care + placebo; Mean change in the ordinal scale and rate of hospital discharges/deaths) |
NCT04869579 (Christus Health and Pharco Pharmaceuticals; United States; August 15, 2021; December 15, 2021) |
| Evaluation of the plasma concentration of micronutrients (selenium, zinc, copper, etc.) in elderly COVID-19 patients and its correlation with the prognosis of COVID-19 | Observational (Cohort; Completed; Not mentioned; 229; Not available; COVID-19 patients of > 50 years; The plasma concentration of selenium, zinc, copper, and vitamin A, D, and E) |
NCT04877509 (Hospices Civils de Lyon; France; March 1, 2020; May 1, 2021) |
| Assessment of the ABBC1 (a nutritional supplement containing selenium and zinc) benefits among volunteers taking influenza and COVID-19 vaccine. The supplementation starts 30 and 35 days after taking the influenza, and COVID-19 vaccine, respectively. | Other (Randomized; Recruiting; Not applicable; 90; Published; Influenza/COVID-19 vaccine + placebo; Change in the immune response and selenium/zinc level after supplementation) |
NCT04798677 (AB Biotek; Spain; October 29, 2020; July 2021) |
| To determine the serum concentration of trace elements (selenium, zinc, copper, etc.) in COVID-19 patients before starting the treatment and to compare the results with a healthy individual | Prospective (Randomized; Completed; Not mentioned; 40; Not available; Healthy individuals; Levels of serum trace elements) |
NCT04694716 (Izmir Bakircay University; Turkey; January 6, 2021; August 15, 2021) |
| Efficacy of micronutrient supplements (once a day oral supplementation comprising vitamins, iron (5 mg), zinc (10 mg), selenium (110 mg), and copper (0.9 mg)) in lowering hospital admissions of COVID-19 patients | Treatment (Randomized; Not yet recruiting; Not applicable; 300; Not available; Placebo dietary supplement; Need for hospital admission) |
NCT04751669 (Fundació Institut Germans Trias i Pujol; Spain; April 1, 2021; December 31, 2021) |
| Understanding the course of COVID-19 among patients treated with an Immuno-Formulation (Immuno-TF) that consists of selenium yeast (48 mg, equivalent to 96 μg of selenium), zinc, ferulic acid, resveratrol, spirulina, N-acetylcysteine, and vitamins along with other ingredients | Observational (Retrospective cohort; Completed; Not mentioned; 40; Not available; COVID-19 patients; Clinical symptoms duration) |
NCT04666753 (Fagron Iberica S.A.U.; Spain; July 2, 2020; September 29, 2020) |
| Reducing the COVID-19 severity by utilizing once a day oral capsule comprising selenium (15 ug), zinc (7.5 mg), vitamin A (1500 mcg), vitamin C (250 mg), and vitamin E (90 mg) for 7–14 days | Supportive Care (Randomized Recruiting 2/3; 40; Not available; cellulose-containing placebo capsules; Change in the serum level of ferritin, Interleukin-6, C-reactive protein, Tumor necrosis factor-α, and monocyte chemoattractant protein 1) |
NCT04323228 (King Saud University; Saudi Arabia; September 1, 2020; December 30, 2020) |
| Understanding the change in the serum concentration of trace elements (selenium, zinc, magnesium, copper, etc.) in COVID-19 patients before and after COVID-19 treatment | Observational (Cohort; Completed; Not mentioned; 15; Not available; Not mentioned; Change of the levels of Trace Element at baseline and discharge) |
NCT04694703 (Izmir Bakircay University; Turkey; January 6, 2021; August 29, 2021) |
| Determination of the oxidative stress indicators (Superoxide dismutase and malondialdehyde), trace elements (selenium, zinc, potassium, sodium, magnesium, and copper), and quality of life among healthy women before and COVID-19 vaccine |
Screening (Not applicable; Not yet recruiting; Not applicable; 20; Not available; Not mentioned; Change of the levels serum trace element) |
NCT04751721 (Izmir Bakircay University; Turkey; February 2021; April 2021) |
| Determination of the oxidative stress indicators (Superoxide dismutase and malondialdehyde), trace elements (selenium, zinc, potassium, sodium, magnesium, and calcium), and quality of life among healthy men before and COVID-19 vaccine |
Screening (Not applicable; Not yet recruiting; Not applicable; 20; Not available; Not mentioned; Change of the levels serum trace element) |
NCT04751695 (Izmir Bakircay University; Turkey; February 2021; April 2021) |
| Determination of the concentration of trace elements (selenium, zinc, and magnesium) along with other parameters to assess their involvement in the generation of fatigue associated with COVID-19 | Diagnostic (Non-Randomized; Recruiting; Not applicable; 102; Not available; Not mentioned; Voluntary maximum force reduction) |
NCT04363606 (Centre Hospitalier Universitaire de Saint Etienne; France; May 27, 2020; December 2022) |