Supplementary Table 2. Risk of MACE according to baseline lipid marker quartiles in low- and high-dose groups.
| Unadjusted | Adjusted | |
|---|---|---|
| A. LDL-C, mg/dL | ||
| Low-dose group | ||
| 1st quartile ≤ 75.2 | 1.00 | 1.00 |
| 2nd quartile ＞ 75.2 to 88.0 | 0.99 (0.68, 1.47) | 1.23 (0.78, 1.93) |
| 3rd quartile ＞ 88.0 to 101.4 | 1.04 (0.71, 1.52) | 1.26 (0. 80, 1.98) |
| 4th quartile 4 ＞ 101.4 | 1.13 (0.78, 1.65) | 1.46 (0.90, 2.38) |
| p for trend | 0.501 | 0.131 |
| High-dose group | ||
| 1st quartile ≤ 75.2 | 1.00 | 1.00 |
| 2nd quartile ＞ 75.2 to 88.0 | 0.78 (0.51, 1.19) | 0.64 (0.39, 1.05) |
| 3rd quartile 3 ＞ 88.0 to 101.4 | 1.00 (0.66, 1.51) | 0.96 (0.60, 1.55) |
| 4th quartile 4 ＞ 101.4 | 0.84 (0.55, 1.27) | 0.85 (0.52, 1.39) |
| p for trend | 0.671 | 0.928 |
| B. Triglycerides, mg/dL | ||
| Low-dose group | ||
| 1st quartile ≤ 90.0 | 1.00 | 1.00 |
| 2nd quartile ＞ 90.0 to 124 | 1.40 (0.95, 2.04) | 1.30 (0.81, 2.05) |
| 3rd quartile ＞ 124 to 175 | 1.47 (1.00, 2.18) | 1.32 (0.84, 2.13) |
| 4th quartile ＞ 175 | 1.59 (1.06, 2.37) | 1.55 (0.93, 2.58) |
| p for trend | 0.024 | 0.091 |
| High-dose group | ||
| 1st quartile ≤ 90.0 | 1.00 | 1.00 |
| 2nd quartile ＞ 90.0 to 124 | 0.75 (0.49, 1.15) | 0.73 (0.43, 1.23) |
| 3rd quartile ＞ 124 to 175 | 1.02 (0.68, 1.54) | 0.94 (0.56, 1.58) |
| 4th quartile ＞ 175 | 0.68 (0.45, 1.05) | 0.64 (0.38, 1.08) |
| p for trend | 0.229 | 0.205 |
| C. TRL-C, mg/dL | ||
| Low-dose group | ||
| 1st quartile ≤ 18.0 | 1.00 | 1.00 |
| 2nd quartile ＞ 18.1 to 24.8 | 1.41 (0.96, 2.07) | 1.31 (0.83, 2.07) |
| 3rd quartile ＞ 24.8 to 35.0 | 1.49 (1.00, 2.20) | 1.34 (0.84, 2.15) |
| 4th quartile ＞ 35.0 | 1.61 (1.09, 2.39) | 1.57 (0.95, 2.59) |
| p for trend | 0.019 | 0.088 |
| High-dose group | ||
| 1st quartile ≤ 18.0 | 1.00 | 1.00 |
| 2nd quartile ＞ 18.1 to 24.8 | 0.74 (0.49, 1.13) | 0.73 (0.43, 1.23) |
| 3rd quartile ＞ 24.8 to 35.0 | 1.00 (0.67, 1.51) | 0.93 (0.55, 1.57) |
| 4th quartile ＞ 35.0 | 0.68 (0.44, 1.04) | 0.65 (0.39, 1.09) |
| p for trend | 0.214 | 0.210 |
Abbreviations: eGFR, estimated glomerular filtration rate; HDL-C, high-density lipoprotein cholesterol; hsCRP, high-sensitivity C-reactive protein; LDL-C, low-density lipoprotein cholesterol; MACE, major adverse cardiovascular events; TRL-C, triglyceride- rich lipoprotein cholesterol.
Data are hazard ratio (95% confidence interval). Multivariable model was adjusted for standard risk factors (i.e., age [≥ 65 and ＜65 years], male sex, body mass index, systolic blood pressure, heart rate, hypertension, diabetes mellitus, smoking status [current versus not current], myocardial infarction history, percutaneous coronary intervention history, coronary artery bypass grafting history, atrial fibrillation, heart failure, malignant disease, and peripheral artery disease), eGFR, hemoglobin A1c, hsCRP, and HDL-C at baseline.