Table I.

Genes involved in the 11 pathways detected using pathway analyses.

Pathway	Genes
DNA damage/telomere stress Induced Senescence	CDKN1A, HIST1H2BC, HIST1H2AC, HIST1H1E, HIST1H2BJ, HIST2H2BE
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors	CDKN1A, APOE, KCTD15
ATF4 activates genes in response to endoplasmic reticulum stress	ATF3, DDIT3
DNA methylation	HIST1H2BC, HIST1H2AC, HIST1H2BJ, HIST2H2BE
SIRT1 negatively regulates rRNA expression	HIST1H2BC, HIST1H2AC, HIST1H2BJ
NCAM signaling for neurite out-growth	3x4Hyp-5Hyl-COL6A2, NCAN, SPTBN4
Transcriptional cascade regulating adipogenesis	KLF2, EGR2, DDIT3
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3	HIST1H2BC, HIST1H2AC, HIST1H2BJ, HIST2H2BE
PRC2 methylates histones and DNA	HIST1H2BC, HIST1H2AC, HIST1H2BJ, HIST2H2BE
Senescence-associated secretory phenotype (SASP)	CDKN1A, HIST1H2BC, HIST1H2AC, HIST1H2BJ, HIST2H2BE
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression	HIST1H2BC, HIST1H2AC, HIST1H2BJ, HIST2H2BE