Table 1.
Characteristics of the 40 patients at the patient and lesion levels
| Characteristics | ||
|---|---|---|
| Patient level (N = 40) | ||
| Age, years | Mean (SD) | 68.3 (8.1) |
| Median | 69 | |
| Range: | 43–80 | |
| 18-59 | 7 (17.5 %) | |
| 60-69 | 15 (37.5 %) | |
| 70-80 | 18 (45 %) | |
| Gender | Male | 22 |
| Female | 18 | |
| Primary tumor | Lung, adenocarcinoma | 24 |
| (EGFR or ALK positive)* | (9) | |
| (EGFR or ALK negative) | (15) | |
| Lung, non-adenocarcinoma | 4 | |
| (Squamous-cell carcinoma) | (2) | |
| (Others) | (2) | |
| Breast | 2 | |
| Kidney | 2 | |
| Colon | 4 | |
| Bladder | 2 | |
| Ovary | 2 | |
| KPS | 100 | 15 |
| 90 | 16 | |
| 80 | 5 | |
| 70 | 4 | |
| Status of Primary cancer | Controlled | 23 |
| Not-controlled | 17 | |
| Extracranial metastases | Absent | 18 |
| Present | 22 | |
| Number of brain metastases | 1 | 21 |
| 2 | 10 | |
| 3 | 5 | |
| 4 | 4 | |
| DS-GPA | 0-1.0 | 2 |
| 1.5-2.0 | 11 | |
| 2.5-3.0 | 19 | |
| 3.5-4.0 | 8 | |
| Neurologic symptom | Symptomatic | 16 |
| Asymptomatic | 24 | |
| Cognitive test score** | ||
| Z-score mean (SD) | HVLT-R total recall | -1.27 (1.24) |
| HVLT-R delay recall | -1.49 (1.25) | |
| HVLT-R delay recognition | -0.76(1.23) | |
| TMT-A | -0.78 (1.42) | |
| TMT-B | -1.31 (1.92) | |
| COWA | -0.27 (1.14) | |
| Lesion level (N = 73) | ||
| Size, maximum diameter (mm) | Median | 11 mm |
| <10 mm | 27 | |
| 10-19 mm | 25 | |
| 20-30 mm | 21 | |
| Radiation method | Single-fraction SRS | 36 |
| Hypo-fractionated SRS | 37 | |
Abbreviations: EGFR, Epidermal Growth Factor Receptor; ALK, Anaplastic Lymphoma Kinase; TKI, Tyrosine Kinase Inhibitor; KPS, Karnofsky Performance Status; DS-GPA, Disease-specific Graded Prognostic Assessment; HVLT-R, Hopkins Verbal Learning Test Revised; TMT, Trail Making Test; COWA, Controlled Oral Word Association.
*
All patients with EGFR or ALK positive lung-adenocarcinoma received Tyrosine Kinase Inhibitor (TKI) treatment.
**
Cognitive tests are reported as standardized score (z-score, transformed so that higher scores indicate better cognitive performance) : (patient value – published-norm mean value)/published-norm standard deviation value.