. 2022 Sep 19;13:299–305. doi: 10.1016/j.ibneur.2022.09.005

Table 2.

Summary of diagnostic findings for patients who had 850k methylation performed.

Patient ID	Histopathological diagnosis	850k methylation diagnosis	Impact on diagnosis
62	Ganglioglioma	Anaplastic pleomorphic xanthoastrocytoma	New diagnosis
73	Unspecified low grade glial tumor	Pilocytic astrocytoma	New diagnosis
7	Diffuse astrocytoma, IDH_mut	Diffuse astrocytoma, IDH_mut	Concordance
57	Diffuse astrocytoma, IDH_mut	Diffuse astrocytoma, IDH_mut	Concordance
79	Diffuse astrocytoma, IDH_mut	Diffuse astrocytoma, IDH_mut	Concordance
214	Diffuse astrocytoma, IDH_mut	Diffuse astrocytoma, IDH_mut	Concordance
152	Pilocytic astrocytoma	Pilocytic astrocytoma	Concordance
188	Ependymoma	Ependymoma	Concordance
27	Glioblastoma, IDH_wt	Glioblastoma, IDH_wt	Concordance
106	Glioblastoma, IDH_wt	Glioblastoma, IDH_wt	Concordance
123	Glioblastoma, IDH_mut	Glioblastoma, IDH_mut	Concordance
164	Glioblastoma, IDH_wt	Glioblastoma, IDH_wt	Concordance
192	Glioblastoma, IDH_wt	Glioblastoma, IDH_wt	Concordance
200	Glioblastoma, IDH_wt	Glioblastoma, IDH_wt	Concordance
226	Glioblastoma, IDH_wt	Glioblastoma, IDH_wt	Concordance
256	Glioblastoma, IDH_wt	Glioblastoma, IDH_wt	Concordance
262	Diffuse midline glioma	Diffuse midline glioma	Concordance
5	Anaplastic astrocytoma, IDH_wt	No match	None
49	Anaplastic astrocytoma, IDH_wt	No match	None
66	Anaplastic Astrocytoma, IDH_wt	No match	None
112	Anaplastic astrocytoma, IDH_wt	No match	None
228	Anaplastic astrocytoma, IDH_wt	No match	None
202	Anaplastic astrocytoma, IDH_wt	No match	None
28	Glioblastoma, IDH_wt	No match	None
48	Glioblastoma, IDH_wt	No match	None
122	Glioblastoma, IDH_wt	No match	None
133	Glioblastoma, IDH_wt	No match	None
210	Glioblastoma, IDH_wt	No match	None
34	Diffuse astrocytoma, IDH_mut	No match	None

Summary for each patient, showing the histopathological diagnosis and the diagnosis provided by 850k methylation and the Heidelberg Classifier. Patients where the Classifier returned with a calibrated score lower than 0.84, were considered as having no match. If the histopathological diagnosis corresponded with the Classifier diagnosis, the impact of methylation profiling was considered as “concordance”. IDHwt; IDH wildtype. IDH_mut; IDH mutant.