Fig. 2.

Hazard ratios (HR) and 95% confidence intervals (CIs) for cancer incidence and mortality among patients with stress-related disorders compared with matched unexposed individuals or unaffected full siblings, before and after semi-Bayes shrinkage, by different sites of cancer

^a Per 1000 person years

^b Cox regression models were stratified by matching identifiers (birth year and sex) and adjusted for educational level, family income level, marital status, family history of specific cancer, Charlson comorbidity index, and history of substance use disorders

^c Cox regression models were stratified by family identifiers and adjusted for birth year, sex, educational level, family income level, marital status, Charlson comorbidity index, and history of substance use disorders

^d For semi-Bayes shrinkage, we specified true population variance of 0.17 and 0.28 for cancer incidence and mortality, implying a prior expectation that 95% of the HRs would fall within a 5-fold range and 8-fold range, respectively