Table 3:

Donor characteristics by exclusive predonation pregnancy complication categories. Donors are only included in 1 complication category. PE/E = Pre-eclampsia; gDM = Gestational Diabetes; gHTN = Gestational Hypertension; DM=diabetes; HTN=hypertension; TIA= transient ischemic attack; BP=Blood Pressure. P-value calculated using Kruskal-Wallis rank sum tests (for variables presented as median [IQR]), ANOVA (for variables presented as mean ± sd), or Fisher’s exact tests (for categorical variables).

	PE/E alone (N=30)	gDM alone (N=34)	gHTN alone (N=32)	More than 1 complication (N=20)	No complications (N=1746)	p- value
Years of follow-up post donation, median [IQR]	20.57 [10.08, 32.99]	15.05 [11.84, 21.22]	27.05 [20.81, 36.05]	13.74 [6.50, 23.04]	18.04 [9.16, 27.56]	0.001
Age, years, at donation	40.07 ± 9.56	42.70 ± 8.79	39.50 ± 10.26	42.86 ± 7.69	42.47 ± 10.61	0.403
Race, n (%)						0.839
Black or African American	1 (3.3%)	0 (0.0%)	1 (3.1%)	1 (5.0%)	43 (2.5%)
Caucasian / White	28 (93.3%)	34 (100.0%)	30 (93.8%)	18 (90.0%)	1640 (93.9%)
Other	1 (3.3%)	0 (0.0%)	1 (3.1%)	1 (5.0%)	49 (2.8%)
Unknown	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	14 (0.8%)
Ethnicity, n (%)						0.472
Hispanic/Latino	1 (3.3%)	1 (2.9%)	1 (3.1%)	0 (0.0%)	49 (2.8%)
Non-Hispanic/Non-Latino	28 (93.3%)	33 (97.1%)	29 (90.6%)	20 (100.0%)	1542 (88.3%)
Unknown	1 (3.3%)	0 (0.0%)	2 (6.2%)	0 (0.0%)	155 (8.9%)
Decade of donation, n (%)						0.014
1960	0 (0.0%)	0 (0.0%)	3 (9.4%)	1 (5.0%)	26 (1.5%)
1970	3 (10.0%)	1 (2.9%)	6 (18.8%)	2 (10.0%)	184 (10.5%)
1980	8 (26.7%)	3 (8.8%)	8 (25.0%)	2 (10.0%)	312 (17.9%)
1990	6 (20.0%)	12 (35.3%)	9 (28.1%)	4 (20.0%)	433 (24.8%)
2000	9 (30.0%)	15 (44.1%)	6 (18.8%)	7 (35.0%)	486 (27.8%)
After 2010	4 (13.3%)	3 (8.8%)	0 (0.0%)	4 (20.0%)	305 (17.5%)
Smoke prior to donation, n (%)						0.915
No	24 (80.0%)	24 (70.6%)	21 (65.6%)	15 (75.0%)	1241 (71.1%)
Yes	6 (20.0%)	10 (29.4%)	10 (31.2%)	5 (25.0%)	433 (24.8%)
Unknown	0 (0.0%)	0 (0.0%)	1 (3.1%)	0 (0.0%)	72 (4.1%)
Family history of DM, n (%)						0.616
No	15 (50.0%)	14 (41.2%)	16 (50.0%)	8 (40.0%)	825 (47.3%)
Yes	15 (50.0%)	17 (50.0%)	16 (50.0%)	12 (60.0%)	808 (46.3%)
Unknown	0 (0.0%)	3 (8.8%)	0 (0.0%)	0 (0.0%)	113 (6.5%)
Family history of HTN, n(%)						0.276
No	12 (40.0%)	19 (55.9%)	18 (56.2%)	13 (65.0%)	994 (56.9%)
Yes	17 (56.7%)	12 (35.3%)	13 (40.6%)	6 (30.0%)	568 (32.5%)
Unknown	1 (3.3%)	3 (8.8%)	1 (3.1%)	1 (5.0%)	184 (10.5%)
Family history of heart disease						0.261
No	18 (60.0%)	21 (61.8%)	20 (62.5%)	10 (50.0%)	1078 (61.7%)
Yes	12 (40.0%)	10 (29.4%)	11 (34.4%)	9 (45.0%)	484 (27.7%)
Unknown	0 (0.0%)	3 (8.8%)	1 (3.1%)	1 (5.0%)	184 (10.5%)
Family history of TIA/Stroke						0.460
No	27 (90.0%)	27 (79.4%)	27 (84.4%)	18 (90.0%)	1407 (80.6%)
Yes	2 (6.7%)	4 (11.8%)	4 (12.5%)	1 (5.0%)	128 (7.3%)
Unknown	1 (3.3%)	3 (8.8%)	1 (3.1%)	1 (5.0%)	211 (12.1%)
Family history of kidney disease, n (%)						0.981
No	8 (26.7%)	10 (29.4%)	9 (28.1%)	6 (30.0%)	530 (30.4%)
Yes	21 (70.0%)	22 (64.7%)	23 (71.9%)	14 (70.0%)	1146 (65.6%)
Unknown	1 (3.3%)	2 (5.9%)	0 (0.0%)	0 (0.0%)	70 (4.0%)
Donation Creatinine, mg/dl	0.82 ± 0.14	0.79 ± 0.11	0.78 ± 0.11	0.84 ± 0.10	0.81 ± 0.12	0.439
Donation Cholesterol, mg/dl	205.00 ± 41.86	206.48 ± 45.70	190.92 ± 24.47	193.00 ± 27.74	192.07 ± 37.36	0.232
Donation BMI, kg/m2	25.96 ± 4.93	27.03 ± 5.63	28.09 ± 6.52	26.01 ± 4.52	25.63 ± 4.42	0.014
Donation Glucose, mg/dl	88.93 ± 9.34	93.88 ± 10.74	91.07 ± 12.75	90.89 ± 13.35	92.34 ± 14.54	0.662
Donation Systolic BP, mmHg	121.33 ± 14.54	118.65 ± 12.45	121.22 ± 16.52	119.58 ± 12.22	118.06 ± 13.02	0.425
Donation Diastolic BP, mmHg	73.80 ± 8.34	70.15 ± 8.77	76.28 ± 12.43	73.05 ± 8.04	71.92 ± 9.74	0.067
Predonation pregnancies	2.87 ± 1.46	3.00 ± 1.33	3.42 ± 1.84	3.70 ± 2.39	2.94 ± 1.67	0.157
Postdonation pregnancies, n (%)
No	24 (80.0%)	32 ( 94.1%)	25 (78.1%)	19 ( 95.0%)	1560 (89.3%)	0.105
Yes	6 (20.0%)	2 ( 5.9%)	7 (21.9%)	1 ( 5.0%)	186 (10.7%)