Figure 2.

Smoothed curves of mean values predicted by generalized estimating equation (GEE) linear models for outpatient systolic and diastolic blood pressure, weight, and body mass index over ten years after bilateral oophorectomy or index date. The predicted values were adjusted by age at index, years of education, and cigarette smoking. Women with hypertension before the index date were excluded from the analyses for systolic and diastolic blood pressure. Weight and body mass index had significant overall group differences and significant interactions with years after index. For both parameters, we also conducted pairwise group comparisons, and the differences were significant for women who did not receive estrogen therapy after bilateral oophorectomy compared to women who did receive estrogen therapy (both p ≤ 0.005) and compared to referent women (both p < 0.001).