Table 3.

Estimated effect of sodium bicarbonate use on outcomes

Outcome	Adjusted odds ratio (95% CI)	Mean difference (95% CI)	P-value
Return of spontaneous circulationa	0.91 (0.62, 1.34)		0.621
Survival to hospital discharge	0.70 (0.54, 0.92)		0.010
Survival to hospital discharge with favorable neurologic outcomeb,c	0.69 (0.53, 0.91)		0.007
Survival to hospital discharge with PCPC of 1, 2, or no worse than baseline	0.80 (0.62, 1.05)		0.105
Change from baseline to hospital discharge in functional status of survivorsb		−0.39 (−0.90, 0.13)	0.139
New morbidity among survivorsd	0.67 (0.45, 0.98)		0.038

Models were weighted using stabilized inverse probability of treatment weights and additionally controlled for site D, site J, creatinine, first documented rhythm, age, illness category and CPR duration.

^aReturn of spontaneous circulation reported is the immediate outcome of the resuscitation event.

^bBaseline Pediatric Cerebral Performance Category (PCPC) and Functional Status Scale (FSS) represent subject status prior to the event leading to hospitalization.

^cFavorable neurologic outcome is defined as no more than moderate disability or no worsening from baseline Pediatric Cerebral Performance Category (PCPC).

^dNew morbidity among survivors is defined as a worsening from baseline functional status by 3 points or more.