Skip to main content
. Author manuscript; available in PMC: 2023 Sep 30.
Published in final edited form as: Circ Res. 2022 Sep 14;131(8):673–686. doi: 10.1161/CIRCRESAHA.121.320661

Figure 1: K180R mice display a CPVT phenotype.

Figure 1:

A. Amino acid 180 is conserved across species in CASQ2. B. K180R knockin mice are heterozygous for the AGG mutation. C. Example EKG traces from a K180R HET mouse, immediately after completing an exercise stress test, displaying characteristics of CPVT including ventricular ectopic beats (VEBs) and an episode of ventricular tachycardia (VT) D. Summary data of exercise-induced ventricular ectopy (VEB/min) and VT incidence. Ventricular arrhythmias were quantified during the 10 min period immediately after completion of the treadmill exercise test. n = 11 mice per group. Data displayed as a box and whisker plot. Median is displayed as a line within the box and whisker plot. Mean is displayed as a plus sign within the box and whisker plot. VEB/min data analyzed using Kruskal-Wallis test with Dunn’s multiple comparisons. VT data analyzed using Fisher’s exact test with pairwise Fisher exact test.