Table 1.
Results for the horizontal pleiotropy, heterogeneity and outlier test.
| pleiotropy | Heterogeneity | MR-PRESSO | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| egger_intercept | se | pval | MR-Egger | IVW | |||||||
| Q | Q_df | Q_pval | Q | Q_df | Q_pval | ||||||
| AD as outcome | Exposure | ||||||||||
| Blood gene expression of CD33 | −0.011 | 0.014 | 0.481 | 2.025 | 3 | 0.567 | 2.669 | 4 | 0.615 | 0.674 | |
| Serum protein level of CD33 | NA | NA | NA | NA | NA | NA | 2.357 | 1 | 0.125 | NA | |
| CD33 on CD14 + monocyte | −0.016 | 0.02 | 0.497 | 6.771 | 3 | 0.08 | 8.109 | 4 | 0.088 | 0.381 | |
| CD33 on CD66b + + myeloid cell | −0.044 | 0.015 | 0.101 | 1.716 | 2 | 0.423 | 10.111 | 3 | 0.018 | 0.369 | |
| CD33 on CD33dim HLA DR + CD11b + | −0.025 | 0.015 | 0.182 | 7.285 | 4 | 0.122 | 12.016 | 5 | 0.035 | 0.312 | |
| CD33 on CD33dim HLA DR + CD11b- | −0.024 | 0.018 | 0.274 | 7.643 | 3 | 0.054 | 12.197 | 4 | 0.016 | 0.246 | |
| CD33 on CD33dim HLA DR- | −0.044 | 0.024 | 0.143 | 7.105 | 4 | 0.13 | 12.991 | 5 | 0.023 | 0.308 | |
| CD33 on basophil | −0.054 | 0.022 | 0.058 | 5.077 | 5 | 0.406 | 11.191 | 6 | 0.083 | 0.39 | |
| CD33 on IMDSC | −0.047 | 0.022 | 0.111 | 3.317 | 4 | 0.506 | 7.476 | 5 | 0.187 | 0.422 | |
| CD33 on GMDSC | −0.04 | 0.026 | 0.37 | 1.774 | 1 | 0.182 | 5.89 | 2 | 0.052 | NA | |
| CD33 on CD33 + HLA DR + | −0.047 | 0.017 | 0.226 | 0.772 | 1 | 0.379 | 8.012 | 2 | 0.018 | 0.372 | |
| CD33 on CD33 + HLA DR + CD14dim | −0.458 | 0.017 | 0.228 | 0.741 | 1 | 0.389 | 7.844 | 2 | 0.02 | 0.4 | |
| CD33 on CD33 + HLA DR + CD14- | −0.047 | 0.017 | 0.226 | 0.806 | 1 | 0.369 | 8.046 | 2 | 0.018 | 0.397 | |
| CD33 on MMDSC | −0.47 | 0.02 | 0.261 | 1.359 | 1 | 0.243 | 8.508 | 2 | 0.014 | 0.404 | |
| AD as exposure | Outcome | ||||||||||
| Blood gene expression of CD33 | 0.006 | 0.012 | 0.651 | 2.419 | 4 | 0.659 | 2.657 | 5 | 0.753 | 0.734 | |
| Serum protein level of CD33 | 0.006 | 0.010 | 0.580 | 10.940 | 16 | 0.813 | 11.259 | 17 | 0.843 | 0.681 | |
| CD33 on CD14 + monocyte | −0.024 | 0.019 | 0.227 | 17.964 | 15 | 0.265 | 19.866 | 16 | 0.226 | 0.273 | |
| CD33 on CD66b + + myeloid cell | −0.006 | 0.025 | 0.803 | 27.424 | 15 | 0.025 | 27.542 | 16 | 0.036 | 0.095 | |
| CD33 on CD33dim HLA DR + CD11b + | −0.020 | 0.018 | 0.289 | 16.398 | 15 | 0.356 | 17.718 | 16 | 0.341 | 0.376 | |
| CD33 on CD33dim HLA DR + CD11b- | −0.019 | 0.018 | 0.327 | 16.505 | 15 | 0.349 | 17.636 | 16 | 0.346 | 0.376 | |
| CD33 on CD33dim HLA DR- | −0.020 | 0.019 | 0.307 | 16.561 | 15 | 0.346 | 17.795 | 16 | 0.336 | 0.452 | |
| CD33 on basophil | −0.024 | 0.018 | 0.214 | 14.342 | 15 | 0.500 | 16.028 | 16 | 0.451 | 0.543 | |
| CD33 on IMDSC | −0.014 | 0.018 | 0.458 | 15.188 | 15 | 0.438 | 15.775 | 16 | 0.469 | 0.56 | |
| CD33 on GMDSC | −0.016 | 0.020 | 0.444 | 11.634 | 15 | 0.707 | 12.253 | 16 | 0.726 | 0.848 | |
| CD33 on CD33 + HLA DR + | −0.022 | 0.023 | 0.346 | 24.195 | 15 | 0.062 | 25.724 | 16 | 0.058 | 0.091 | |
| CD33 on CD33 + HLA DR + CD14dim | −0.025 | 0.023 | 0.293 | 23.254 | 15 | 0.079 | 25.096 | 16 | 0.068 | 0.088 | |
| CD33 on CD33 + HLA DR + CD14- | −0.021 | 0.023 | 0.371 | 23.156 | 15 | 0.081 | 24.470 | 16 | 0.080 | 0.117 | |
| CD33 on MMDSC | −0.039 | 0.020 | 0.068 | 17.746 | 15 | 0.276 | 22.318 | 16 | 0.133 | 0.156 | |