Table 3.

Mean plasma levels of biomarkers along hormonal pathway across the study time points.

Hormone	Mean (± SD) plasma levels			ANOVA	Post-hoc Testa
	T1	T2	T3	p-value	T2-T1 p-value	T3-T2 p-value	T3-T1 p-value
Pooled DHEAS
(µM) (n = 242)	2.80 ± 1.94	2.03 ± 1.56	1.96 ± 1.51	< 0.001	< 0.001	0.39	< 0.001
Pooled DHEA
(nM) (n = 242)	14.49 ± 10.92	13.37 ± 12.65	12.14 ± 10.95	0.09	0.13	0.09	< 0.001
Estradiol
(pM) (n = 161)	191.90 ± 232.18	94.74 ± 116.64	98.21 ± 150.91	< 0.001	< 0.001	0.78	< 0.001

^aBolded values indicate statistical significance with cut-off for Bonferroni-post hoc set at 0.0167.