Table 4.
Change in mean biomarker levels from baseline stratified by impairment status at 6 and 12 weeks from baseline.
| Time period: 6 weeks | Total global FACT-Cog score | PCI sub-scale | ||||||
|---|---|---|---|---|---|---|---|---|
| Pooled Biomarker | Status | Change in mean levels (SD) | Adjusted difference in status variable βa (95% CI) |
p-value | Status | Change in mean levels (SD) |
Adjusted difference in status variable βb (95% CI) |
p-value |
|
DHEAS (μM) |
Impaired (n = 71) |
−0.56 (1.18) |
0.40 (0.05, 0.74) |
0.024 |
Impaired (n = 83) |
−0.54 (1.18) |
0.40 (0.07, 0.74) |
0.018 |
|
Non-impaired (n = 171) |
−0.86 (1.20) |
Non-impaired (n = 159) |
−0.90 (1.20) |
|||||
|
DHEA (nM) |
Impaired (n = 72) |
−0.64 (11.57) |
1.79 (−1.44, 5.01) |
0.28 |
Impaired (n = 83) |
−0.92 (13.62) |
0.96 (−2.16, 4.08) |
0.55 |
|
Non-impaired (n = 171) |
−1.33 (11.58) |
Non-impaired (n = 159) |
−1.24 (10.36) |
|||||
|
Estradiol (pM) |
Impaired (n = 48) |
−106.92 (133.86) |
−1.99 (−53.93, 49.95) |
0.94 |
Impaired (n = 56) |
−115.23 (163.97) |
−1.45 (−56.90, 54.00) |
0.96 |
|
Non-impaired (n = 113) |
−92.18 (163.84) |
Non-impaired (n = 106) |
−89.78 (152.08) |
|||||
| Time period: 12 weeks | Total global FACT-Cog score | PCI sub-scale | ||||||
|---|---|---|---|---|---|---|---|---|
| Pooled Biomarker | Status | Change in mean levels (SD) |
Adjusted difference in status variable βa (95% CI) |
p-value | Status | Change in mean levels (SD) |
Adjusted difference in status variable βb (95% CI) |
p-value |
|
DHEAS (µM) |
Impaired (n = 71) |
−0.81 (1.05) |
0.06 (−0.28, 0.41) |
0.72 |
Impaired (n = 83) |
−0.89 (1.22) |
0.16 (−0.17, 0.49) |
0.33 |
|
Non-impaired (n = 171) |
−0.85 (1.21) |
Non-impaired (n = 159) |
−0.74 (1.03) |
|||||
|
DHEA (nM) |
Impaired (n = 72) |
−1.07 (13.50) |
2.30 (−0.73, 5.32) |
0.14 |
Impaired (n = 83) |
−1.99 (11.93) |
0.85 (−2.09, 3.78) |
0.57 |
|
Non-impaired (n = 171) |
−2.88 (9.25) |
Non-impaired (n = 159) |
−2.54 (10.00) |
|||||
|
Estradiol (pM) |
Impaired (n = 48) |
−127.69 (152.19) |
−37.42 (−101.21, 26.37) |
0.25 |
Impaired (n = 56) |
−131.40 (154.36) |
−27.28 (−95.62, 41.05) |
0.43 |
|
Non-impaired (n = 113) |
−81.02 (198.35) |
Non-impaired (n = 106) |
−81.68 (195.89) |
|||||
Βeta-coefficient represents the linear regression difference in mean biomarker levels between cognitive status for at least two time points (6 weeks relative to baseline and/or 12 weeks relative to baseline). Status is defined by reduction of more than 10.6 points in the total FACT-Cog scores a and by reduction of 8.8 points in the PCI-sub scale b respectively. Reference group refers to non-cognitively impaired patients. Adjusted model accounts for baseline levels of fatigue, anxiety, insomnia, menopausal status and age. Bolded values indicated statistical significance.