Table 2:
Differentially Expressed MicroRNAs in ACR and AMR
| ACR MicroRNAs | Mean Expression | log2 Fold Change | Fold Change | Standard Error | Statistic | P value |
|---|---|---|---|---|---|---|
| miR-223-3p | 45940 | −0.93 | 0.52 | 0.25 | −3.70 | 0.000 |
| miR-361-3p | 1049 | 0.42 | 1.34 | 0.14 | 2.93 | 0.003 |
| miR-3615 | 1364 | −0.43 | 0.74 | 0.16 | −2.75 | 0.006 |
| miR-24-3p | 37695 | −0.39 | 0.76 | 0.16 | −2.46 | 0.014 |
| miR-182-5p | 790 | 0.72 | 1.65 | 0.30 | 2.41 | 0.016 |
| miR-374a-5p | 883 | 0.42 | 1.34 | 0.18 | 2.28 | 0.023 |
| miR-23a-3p | 57985 | −0.39 | 0.76 | 0.17 | −2.27 | 0.023 |
| miR-30e-5p | 78017 | −0.18 | 0.88 | 0.09 | −2.09 | 0.037 |
| miR-582-3p | 340 | −0.95 | 0.52 | 0.46 | −2.04 | 0.041 |
| miR-130b-3p | 442 | −0.41 | 0.75 | 0.20 | −2.03 | 0.042 |
| miR-326 | 92 | −1.05 | 0.48 | 0.52 | −2.03 | 0.043 |
| miR-1299 | 100 | −2.25 | 0.21 | 1.14 | −1.98 | 0.048 |
| AMR MicroRNAs | Mean Expression | log2 Fold Change | Fold Change | Standard Error | Statistic | P value |
| miR-23a-3p | 58794 | −0.80 | 0.57 | 0.20 | −3.94 | 0.000 |
| miR-145-5p | 605 | −1.30 | 0.41 | 0.36 | −3.62 | 0.000 |
| miR-1249-3p | 411 | −1.31 | 0.40 | 0.39 | −3.32 | 0.001 |
| miR-27a-3p | 28287 | −0.74 | 0.60 | 0.22 | −3.32 | 0.001 |
| miR-215-5p | 815 | −1.76 | 0.30 | 0.54 | −3.23 | 0.001 |
| miR-145-3p | 1324 | −0.90 | 0.54 | 0.30 | −3.04 | 0.002 |
| miR-10b-5p | 24845 | −0.82 | 0.57 | 0.27 | −2.98 | 0.003 |
| miR-582-3p | 338 | −1.57 | 0.34 | 0.55 | −2.86 | 0.004 |
| let-7b-3p | 1349 | −0.55 | 0.68 | 0.20 | −2.80 | 0.005 |
| miR-142-3p | 1193 | 0.78 | 1.72 | 0.28 | 2.78 | 0.005 |
| miR-450b-5p | 1643 | −0.85 | 0.55 | 0.31 | −2.76 | 0.006 |
| miR-140-5p | 506 | 0.84 | 1.79 | 0.31 | 2.71 | 0.007 |
| miR-374a-5p | 906 | 0.57 | 1.48 | 0.22 | 2.57 | 0.010 |
| miR-17-5p | 1609 | 0.61 | 1.53 | 0.24 | 2.56 | 0.010 |
| miR-143-3p | 51349 | −0.90 | 0.54 | 0.35 | −2.55 | 0.011 |
| miR-130b-3p | 463 | −0.55 | 0.68 | 0.23 | −2.37 | 0.018 |
| miR-1-3p | 3288 | −0.93 | 0.52 | 0.40 | −2.34 | 0.019 |
| miR-542-3p | 738 | −0.80 | 0.57 | 0.35 | −2.28 | 0.022 |
| miR-484 | 9962 | 0.51 | 1.42 | 0.23 | 2.22 | 0.027 |
| miR-345-5p | 1217 | −0.67 | 0.63 | 0.31 | −2.16 | 0.031 |
| miR-125a-5p | 9648 | −0.57 | 0.67 | 0.27 | −2.14 | 0.032 |
| miR-338-5p | 879 | −0.92 | 0.53 | 0.43 | −2.11 | 0.035 |
| miR-769-5p | 351 | −0.97 | 0.51 | 0.46 | −2.10 | 0.036 |
| miR-193a-5p | 3018 | −0.67 | 0.63 | 0.32 | −2.08 | 0.038 |
| miR-454-3p | 858 | 0.63 | 1.55 | 0.31 | 2.06 | 0.040 |
| miR-223-5p | 2258 | −0.84 | 0.56 | 0.43 | −1.97 | 0.049 |
| let-7d-3p | 24761 | −0.26 | 0.84 | 0.13 | −1.97 | 0.049 |
*
We screened plasma miRs to identify differentially expressed miRs in ACR and AMR while adjusting for clinical covariates (age, sex, race, body-mass index). We adjusted for blood group in a subset of patients with minimal change in the miR profile. The table represents all differentially expressed miRs in ACR and AMR with an unadjusted p-value < 0.05.