Table 2.
Drugs changed the thermal stability of Mtb EF-Tu.
| Name | Target | Pathway | Tm (°C) |
|---|---|---|---|
| Doxazosin | Adrenergic receptor | Neuronal signaling | 47 |
| Fenoterol hydrobromide | Adrenergic receptor | Neuronal signaling | 45.4 |
| Metoprolol tartrate | Adrenergic receptor | Neuronal signaling | 59.5 |
| Domperidone | Dopamine receptor | Neuronal signaling | 45.8 |
| Alvimopan | Opioid receptor | Neuronal signaling | 56.9 |
| Motolimod | TLR | Immunology | 48 |
| Montelukast | LTR | Immunology | 43.2 |
| Estriol | Estrogen receptor | Endocrinology | 44 |
| Aliskiren temifumarate | RAAS | Endocrinology | 46.8 |
| Canagliflozin hemihydrate | SGLT | GPCR & G protein | 44.1 |
| Lixisenatide | Glucagon receptor | GPCR & G protein | 55.4 |
| Osimertinib (AZD9291) | EGFR | Protein tyrosine kinase | 60.2 |
| Saracatinib (AZD0530) | Src | Angiogenesis | 61.1 |
| Carvedilol Phosphate | Others | Others | 75.9 |
| Thioridazine hydrochloride | Others | Others | 58 |
| Aliskiren | Others | Others | 46.7 |