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. 2022 Oct 3;12:16543. doi: 10.1038/s41598-022-20979-x

Table 5.

Evaluation results about the emerging circuits for the simulation chosen as example.

Connectome nodes Brodmann areas Cognitive functions Evaluation with the real process
Circuit 1

{4,46}

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2R,28R

The Primary Somatosensory Cortex bound with the Entorhinal cortex

Area 2 analyzes size and shape of stimuli

Area 28R identifies the space configuration

Believable
Circuit 2

{9,71}

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5L,43L

The Somatosensory Association Cortex bound with the Primary gustatory cortex

Area 5 integrates sensorial stimuli

Area 43 is the primary gustatory cortex, but it is active also in semantic tasks

Unbelievable, it could be positive if Area 5 is connected to areas 41 and 42 (Auditory cortex)
Circuit 3

{23,30}

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17L,20R

The Primary visual cortex (V1) bound with the Inferior temporal gyrus

Area 17 processes the visual information

Area 20 is involved in the recognition of complex object features, face perception, numbers

Believable
Circuit 4

{33,45}

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22L,28L

The Superior temporal gyrus bound with the Ventral entorhinal cortex

Area 22 is involved in speech processing

Area 28, near the hippocampus, is related to spatial memories

Believable
Circuit 5

{37,42}

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24L,26R

The Ventral anterior cingulate cortex bound with the Retrosplenial region of the cerebral cortex

Area 24 is related to emotion formation and processing, learning, and memory

Area 26 plays a probable role in mediating between perceptual and memory functions

Believable
Circuit 6

{37,55}

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{24L,35L}

The Ventral anterior cingulate cortex bound with the Perirhinal cortex

Area 24 is related to emotion formation and processing, learning, and memory

Area 35 is heavily related to memory processes

Believable
Circuit 7

{51,71}

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{32L,43L}

The Dorsal anterior cingulate cortex bound with the Primary gustatory cortex (probably 41 and 42)

Area 32 is involved in rational thought processes

Area 43 is the primary gustatory cortex, but it is active also in semantic tasks

Unbelievable
Circuit 8

{70,76}

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{42R,45R}

The Auditory cortex bound with the Pars triangularis with part of the inferior frontal gyrus and part of the Broca's area

Area 42 receives input from the ears, transmits signals back, connects with other parts of the cerebral cortex

Area 45 is related to semantic decision tasks (abstract or concrete nouns discrimination) generation task (generation of a verb associated with a noun)

Believable
Circuit 9

{9,51,71}

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5L,32L,43L

The Somatosensory Association Cortex bound with the Dorsal anterior cingulate cortex, bound with the Primary gustatory cortex

Area 5 integrates sensorial stimuli

Area 32 is involved in rational thought processes

Area 43 is the primary gustatory cortex, but it is active also in semantic tasks

Unbelievable
Circuit 10

{37,42,55}

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{24L,26R,35L}

The Ventral anterior cingulate cortex bound with the Ectosplenial portion of the retrosplenial region of the cerebral cortex bound with the Perirhinal cortex

Area 24 is related to emotion formation and processing, learning, and memory

Area 26 plays a probable role in mediating between perceptual and memory functions

Area 35 is heavily related to memory processes

Believable

It is reasonable to think that most of the circuits are congruent with the simulated cognitive behavior.