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. 2022 Oct 3;13(10):844. doi: 10.1038/s41419-022-05292-9

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — A–D MLN4924 treatment increases PD-L1 protein levels and mRNA levels in dose- and time-dependent manners. H358 and BxPC3 Cells were treated with various concentrations of MLN4924 for the indicated time periods, followed by IB with the indicated Abs (A, B), or followed by qRT-PCR analysis (C, D). E, F MLN4924 treatment increases the cell surface PD-L1 levels in dose- and time-dependent manners. H358 and BxPC3 Cells were treated with various concentrations of MLN4924 for the indicated time periods, followed by FACS analysis. MFI Median Fluorescence Intensity; p < 0.05 (*).