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. 2022 Oct 3;13(10):844. doi: 10.1038/s41419-022-05292-9

Fig. 5. MEK inhibitor enhances cytotoxic effect of Jurkat cells on MLN4924-pretreated cancer cells.

Fig. 5

A, B H358 cells were treated with either MLN4924 (0.5 μM) or indicated inhibitors or both for 24 h, then co-cultured with Jurkat cells for 24 h. The H358 and Jurkat cells were separately harvested for IB with the indicated Abs. C H358 cells were treated with either MLN4924 (0.5 μM) or indicated inhibitors or both for 24 h, co-cultured with PHA/PMA-activated Jurkat cells for 24 h, followed by crystal violet staining and photography. Shown are mean ± SEM of three independent experiments. p < 0.05 (*), p < 0.01 (**). NC negative control without Jurkat co-culture nor drug treatment.