Figure 4.

The molecular mechanism underlying the anti-proliferative effect of EZH inhibitors in MRT cells

(A) Venn diagram of the differentially expressed genes (false discovery rate adjusted p < 0.05, and fold-change > 2). A204.1 cells were treated with DS-3201b (100 nM) or EPZ-6438 (100 nM) for 14 days, followed by RNA-sequencing (RNA-seq) analysis. The number in each circle represents the number of differentially expressed genes between DS-3201b treatment and EPZ-6438 treatment. (B) The enrichment analysis of the differentially expressed genes using Metascape. Bar graphs colored by p value show the top 20 enriched terms, specifically changed by DS-3201b treatment (top), overlapped between DS-3201b and EPZ-6438 (middle), and altered by EPZ-6438 treatment (bottom).