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IC50 values of EZH inhibitors in MRT and RMS cell lines
| Cell line | Origin | IC50 (nM, day 11) |
||||
|---|---|---|---|---|---|---|
| DS-3201b | UNC1999 | CPI-360 | GSK126 | EPZ-6438 | ||
| TTC642 | soft tissue | 0.19 | 3.77 | 23.21 | 78.7 | 37.1 |
| A204.1 | soft tissue | 0.47 | 12.3 | 33.9 | 749 | 399.7 |
| G401.6TG | kidney | 13.3 | 76.7 | 68.5 | 261.1 | 112.6 |
| KYM-1 | soft tissue | 20.6 | 179.7 | 219.0 | 489.9 | 593.2 |
| JMU-RTK-2 | kidney | 101.3 | 177.3 | 289.7 | 393.4 | 468.7 |
| TTC549 | liver | 526.0 | 900.2 | 772.1 | 1097 | 1233 |
| RD | soft tissue (RMS) | 1303 | 2698 | 1442 | 3942 | 7756 |
