Table 2.
Distribution of HIV risk characteristics in HPTN 082 cohort over follow-up1
| Enrollment (N=427) | Week 13 (N=380) | Week 26 (N=373) | Week 52 (N=369) | p-value2 | |
|---|---|---|---|---|---|
|
| |||||
| Any HIV risk in the prior three months3 | 364 (85%) | 226 (60%) | 243 (65%) | 224 (61%) | <0.0001 |
|
| |||||
| Any condomless vaginal or anal sex4 | 271 (63$) | 129 (34%) | 109 (29%) | 106 (29%) | <0.0001 |
|
| |||||
| Report a primary partner living with HIV, who was not taking ARVs or has unknown ARV use | 1 (0%) | 4 (1%) | 2 (1%) | 2 (1%) | 0.96 |
|
| |||||
| Report a primary partner with unknown HIV status | 69 (16%) | 49 (13%) | 50 (13%) | 44 (12%) | 0.24 |
|
| |||||
| >1 sexual partner | 130 (30%) | 72 (19%) | 64 (17%) | 58 (16%) | <0.0001 |
|
| |||||
| Any STI diagnosis5 | 162 (38%) | --- | 82 (22%) | 82 (22%) | <0.0001 |
|
| |||||
| Report of transactional sex | 97 (23%) | 58 (15%) | 67 (18%) | 54 (15%) | 0.022 |
|
| |||||
| Report of drug use before or during sex | 22 (5%) | 13 (3%) | 14 (4%) | 16 (4%) | 0.81 |
|
| |||||
| Report of alcohol use before or during sex | 109 (26%) | 80 (21%) | 87 (23%) | 80 (22%) | 0.89 |
|
| |||||
| Levels of HIV risk | <0.0001 | ||||
| 0 HIV risk factors | 63 (15%) | 153 (40%) | 130 (35%) | 135 (37%) | |
| 1 HIV risk factors | 94 (22%) | 115 (30%) | 108 (29%) | 108 (29%) | |
| 2 HIV risk factors | 126 (30%) | 61 (16%) | 74 (20%) | 70 (19%) | |
| ≥3 HIV risk factors | 144 (34%) | 50 (13%) | 61 (16%) | 56 (15%) | |
ARV=antiretroviral medication; STI=sexually transmitted infection; TFV-DP=tenofovir diphosphate; TFV=tenofovir
Data are presented as median (interquartile range) for continuous variables and frequency (percentage) for categorical variables
p-value for trend based on regression model assessing whether frequencies significantly differed by visit
Any HIV risk was defined as reporting at least one of the following at a given study visit: condomless vaginal or anal sex; reporting a primary partner living with HIV who was not known to be taking antiretrovirals; reporting a primary partner with unknown HIV status; more than one sexual partner; any STI diagnosis; reporting transactional sex; reporting drug and/or alcohol use before or during sex
A participant was considered to engage in condomless sex if they endorsed the responses of “never”, “rarely”, “sometimes”, or “often” (versus “always”) when asked about vaginal and anal sex acts since in the prior three months.
STI testing was not done at Week 13