Figure 4:
Summary of the applications (larger portion of graph) and main functional readouts (extruded section) in microphysiological models used to investigate contributing factors to neovascularization. Main biophysical factors studied in microfluidics include the response to Shear Stress98, Interstitial Forces75, Cell-Cell interactions99, Extracellular matrix84. The principal biochemical factors studied are Soluble Factors85 and Hypoxia100. The main functional evaluated in microfluidic models are vessel permeability56 and angiogenic sprouting101. Figures reproduced with permissions.