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. 2022 Oct 3;13:5829. doi: 10.1038/s41467-022-33189-w

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — CMPs: common myeloid progenitors. Both of the genes JAK2 and TET2 are mutated in myeloproliferative neoplasms, but different orders of the mutation can lead to distinct changes in the cell types that expand, drug sensitivity, and time of presentation in the clinic.