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. 2022 Oct 3;13:5661. doi: 10.1038/s41467-022-33004-6

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a Examples of design models. b Simulated folding energy landscapes, with each dot representing the lowest energy structure obtained from ab initio folding trajectories starting from an extended chain (red dots) or local relaxation of the designed structure (green dots). The x-axis depicts the Cα-RMSD from the designed model and the y-axis, the Rosetta all-atom energy. c Far-ultraviolet circular dichroism spectra (blue: 25 °C; green: 55 °C; red: 75 °C; black: 95 °C). d Far-ultraviolet circular dichroism spectra at different guanidine hydrochloride concentrations and at 25 °C (blue: 0 M; green: 1 M; red: 2 M; cyan: 3 M; yellow: 4 M; magenta: 5 M; gray: 6 M; black: 7 M).