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. 2022 Oct 3;2:125. doi: 10.1038/s43856-022-00180-x

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — The partial dependence plots show the change in relative 5-year mortality risk for all values of a given laboratory feature. The grey histograms on each plot show the distribution of values for that feature in the test set. The green shaded region shows the reference interval of each feature. The grey dotted line shows the average value of the model predicted probability (y = 1). a–e The partial dependence plots of the features whose reference intervals are optimal for mortality risk. f–j The partial dependence plots of the features whose reference intervals are sub-optimal for mortality risk.