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. 2022 Sep 20;13:987639. doi: 10.3389/fimmu.2022.987639

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Copyright © 2022 Signorelli, Ghidotti, Proto, Brambilla, De Toma, Ferrara, Galli, Ganzinelli, Lo Russo, Prelaj, Occhipinti, Viscardi, Capizzuto, Pontis, Petraroia, Ferretti, Colombo, Torri, Sozzi, Garassino, Jachetti and Fortunato

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R-EVs and NR-EVs do not affect T cell proliferation and activation. CFSE labeled CD8⁺ and CD4⁺T cells isolated from healthy donor PBMCs were primed in vitro with CD3/CD28, either alone (Ctrl+) or in presence of EV from Responder (R) or non responder patients (NR). Negative control T cells were left not stimulated (ns). Histograms show absolute numbers of CD8+ and CD4+ lymphocytes and proliferation (measured as CFSE dilution) and percentage of IFNγ⁺, PD1⁺, and Granzyme B⁺ cells within either CD8+ or CD4+ T cells. *p<0.05; **p<0.01; ns, not stimulated.