Fig. 3. Temporal brain dynamics shift under psychedelics.

a k-means clustering of the BOLD time series resulted in a brain state time series for each of the individuals’ two scans²⁹. We then calculated each brain states’ (left) fractional occupancy, (center) average dwell time, and (right) average number of appearances per minute for each individual and condition in the b LSD and c psilocybin datasets. Comparisons were made using two-sided t-tests and p-values were corrected for multiple comparisons (Benjamini-Hochberg) where indicated. *uncorrected p < 0.05, **corrected p < 0.05. Source data are provided as a Source Data file.