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. 2022 Oct 3;13:5812. doi: 10.1038/s41467-022-33578-1

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — We weighted our model with expression maps of other serotonin receptors (5-HT1a, 5-HT1b, and 5-HT4), and the serotonin transporter (5-HTT), and found that 5-HT2a resulted in significantly lower transition energy (averaged across all pairs of states) than all others. (left) Energies calculated from each subject’s placebo centroids in the LSD dataset (n = 15). (right) Energies calculated from each subject’s placebo centroids in the psilocybin dataset (n = 9). On each box, the central line indicates the median, the top and bottom lines refer to the 75th and 25th percentiles, respectively, and the whiskers extend to the most extreme values not considered outliers. Comparisons between 2a energies and all other profiles within each dataset were made using two-sided t-tests. P-values were corrected for multiple comparisons (Benjamini-Hochberg). **corrected p < 0.05. Source data are provided as a Source Data file.