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. 2022 Oct 3;13(10):845. doi: 10.1038/s41419-022-05291-w

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — A Representative images of spheroids formed by OVCAR3 cells in Matrigel (left). The invasive spheroids were featured by scattered protrusions formed on the spheroid surface, as indicated by yellow arrows. Scale bar, 50 μm. Proportion of two spheroid types in OVCAR3-CON and OVCAR3-DHRS2 cells (right) (p < 0.05). Stable OVCAR3-CON and OVCAR3-DHRS2 cells were injected into the abdominal cavity, respectively (n = 6 per group). B During the experiment, the body weight of the mice was determined every 3 days and shown in the graph. C Representative intraperitoneal metastatic tumors in the designated group. D, E The amount and mass of the metastatic tumors were shown in the graph. F The protein levels of DHRS2, CHKα, p-AKT, and perilipin1 in tumor tissues of the designated group. G Representative images of tumor sections in each group stained with indicated antibodies. H The representative images of DHRS2 staining in OC tissues and non-tumor tissues. The scatter diagram shows Histoscore for DHRS2 staining in the designated samples. Data are shown as mean values ± S.D. of independent, triplicate experiments. The asterisks (*,**,***) indicate significant differences (p < 0.05, p < 0.01, p < 0.001, respectively).