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. 2022 Oct 3;13:5820. doi: 10.1038/s41467-022-33331-8

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a Pathway enrichment analysis (IPA) of the differentially expressed genes in patients enrolled in UNIFI with high enrichment for the IL-22 transcriptional program (right-tailed Fisher’s exact test), b genes belonging to “Migration of cells” pathway that are upregulated in patients with high enrichment of the IL-22 transcriptional program, as identified using IPA downstream analysis. Genes have been further subdivided into functional categories. Symbols denote type of protein, color denotes regulation and color of line denotes relationship, c regulator effects analysis performed on the top 3 predicted upstream activators by IPA in the patients with high enrichment for the IL22 transcriptional program, d normalized expression intensity (to healthy controls, n = 18) of known IL-22 regulators stratified by the IL-22 transcriptional program enrichment (UNIFI, UC n = 550, Kruskal–Wallis test with Dunn multiple comparisons test, *p < 0.05, **p < 0.01, ***p < 0.001). Source data for a and d are provided as a Source Data file.