Figure 5.

Longitudinal analysis of wild-type (WT) S and S, N and M protein peptide pool-specific interferon-γ (IFN-γ)⁺ CD4⁺ and CD8⁺ T cells by vaccine brand and route. S-specific IFN-γ⁺ CD4⁺ and CD8⁺ T cell responses are shown in (A, B) respectively for both BNT162b2 and CoronaVac recipients, while added SNM-specific IFN-γ⁺ CD4⁺ and CD8⁺ T cell responses are shown in (C, D) for CoronaVac recipients. Samples from the same patient were paired between baseline and post-dose 2 timepoints as well as post-dose 2 and post-dose 3 timepoints, and compared with paired t test after natural logarithmic transformation with p-values denoted (**, P<0.01; ns, not significant).