Figure 7.

Histopathological evidence reveals that miR-150-5p ameliorates OA progression. (A) Specimens from the four groups were immunostained with H&E in four independent experiments, Safranin-O (four independent experiments), VCAM-1 (six independent experiments), or CD11b (six independent experiments). (B) OARSI scores were evaluated in three independent experiments and (C) cartilage degeneration scores were evaluated in four independent experiments. (D, E) IHC staining intensity was scored as absent (no staining, score 0), weak (1–20% staining, score 1), weak-moderate (21–40%, score 2), moderate (41–60%, score 3), moderate intensity (61–80%, score 4) and strong (81–100%, score 5). IHC staining data were scored in six independent experiments for both VCAM-1 and CD11b expression. ** p < 0.01, **** p < 0.0001 compared with Controls; ^## p < 0.01, ^#### p < 0.0001 compared with ACLT rats.