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. 2022 Sep 20;12:941552. doi: 10.3389/fonc.2022.941552

Figure 3.

Figure 3

T3 modifies the global miRNA expression profile of preneoplastic lesions (A) Hierarchical clustering of miRNA in preneoplastic lesions untreated (nodules) or treated with T3 for 4 days (nodules +T3). Each row represents the expression of a gene and each column a sample. Red and green colors represent higher or lower miRNA expression levels (median-centered), respectively; (B) Principal component analysis (PCA) indicative of the variability of miRNA expression data in nodules untreated or treated with T3 for 4 days; (C) Volcano plot of the 28 significantly differentially expressed miRNAs. Red dots indicate the miRNAs which qualify the P-value of 0.05 and Fold Change (FC) 1.4. Green and grey triangles indicate miRNAs which did not pass the P-value and Fold change cutoff respectively; (D) List of miRNAs differentially up- and down-regulated in nodules of rats fed T3 for 4 days vs. nodules of untreated animals.