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. 2022 Jul 28;13(5):2480–2491. doi: 10.1002/jcsm.13035

Figure 2.

Figure 2

Cisplatin exacerbates muscle wasting in aged mice which is combatted by elevated skeletal muscle PGC1α. Gastrocnemius, tibialis anterior, and quadriceps weights normalized to initial body weight (IBW) of wild‐type (WT) and PGC1α transgenic (Tg) mice treated with cisplatin (C: 2.5 mg/kg) or vehicle for 14 days. Row 1 (A–C): 2‐month‐old male WT, Tg, WT + C, Tg + C (n = 5); row 2 (D–F): 2‐month‐old female WT, Tg, WT + C, Tg + C (n = 5); row 3 (G‐I): 18‐month‐old male WT, Tg, WT + C, Tg + C (n = 5–9); row 4 (J–L): 18‐month‐old female WT, Tg, WT + C, Tg + C (n = 5–9). Data are expressed as mean ± SD. Significance of the differences: *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001 versus WT; $ P < 0.05, $$ P < 0.01, $$$ P < 0.001, $$$$ P < 0.0001 versus Tg; # P < 0.05, ## P < 0.01, ### P < 0.001 versus WT + C.