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. 2022 Jul 28;13(5):2480–2491. doi: 10.1002/jcsm.13035

Figure 4.

Figure 4

Overexpression of muscle PGC1α preserves MUNE in young and aged mice treated with cisplatin. Compound muscle action potential [CMAP: Millivolts (mV)], single motor unit potential [SMUP; microvolts (μV)], and motor unit number estimation (MUNE) of wild‐type (WT) and PGC1α transgenic (Tg) mice treated with cisplatin (C: 2.5 mg/kg) or vehicle for 14 days. Row 1 (A–C): 2‐month‐old male WT, Tg, WT + C, Tg + C (n = 5); row 2 (D–F): 2‐month‐old female WT, Tg, WT + C, Tg + C (n = 5); row 3 (G–I): 18‐month‐old male WT, Tg, WT + C, Tg + C (n = 5–9); row 4 (J–L): 18‐month‐old female WT, Tg, WT + C, Tg + C (n = 5–9). Data are expressed as mean ± SD. Significance of the differences: *P < 0.05, **P < 0.01, ***P < 0.001 versus WT; $$ P < 0.01, $$$ P < 0.001, $$$$ P < 0.0001 versus Tg; # P < 0.05, ## P < 0.01, ### P < 0.001 versus WT + C.