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. 2022 Aug 4;13(5):2537–2550. doi: 10.1002/jcsm.13050

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© 2022 The Authors. Journal of Cachexia, Sarcopenia and Muscle published by John Wiley & Sons Ltd on behalf of Society on Sarcopenia, Cachexia and Wasting Disorders.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Lower exercise capacity in MS. Variables determined during cardiopulmonary exercise testing in MS patients and healthy controls. Black circles represent individual participant values. (A) Peak oxygen uptake (V̇O_2peak) in MS patients versus controls. (B) Relationship between V̇O_2peak and score on the expanded disability status scale (EDSS) within the MS patients. (C) Peak heart rate (HR_peak) in MS patients versus controls. (D) Peak O₂ pulse (O₂ pulse_peak), determined as V̇O_2peak/HR_peak in MS patients versus controls. (E) Gain of the relationship between V̇O₂ and change in external power output in MS patients versus controls. (F) Gas exchange threshold (GET) in MS versus controls. (G) Respiratory compensation point (RCP) in MS versus controls. *P < 0.05; **P < 0.01. Mean ± SD.