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. 2022 Aug 4;13(5):2537–2550. doi: 10.1002/jcsm.13050

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© 2022 The Authors. Journal of Cachexia, Sarcopenia and Muscle published by John Wiley & Sons Ltd on behalf of Society on Sarcopenia, Cachexia and Wasting Disorders.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Normal muscle fibre size and composition in MS. Vastus lateralis biopsies were obtained from MS patients and healthy controls. (A) Representative immunohistochemistry images showing the presence of myosin heavy chain type I, IIa, and IIx, delineated by laminin‐stained cell membranes. Scale bar: 75 μm. (B) Muscle fibre type composition of type I, IIa, and IIa/x fibres in MS and controls. (C) Fibre cross‐sectional area (FCSA) of type I, IIa, and IIa/x fibres in MS and controls. **P < 0.01 for main effect of fibre type (from mixed model analysis). Mean ± SD.