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. 2022 Aug 4;13(5):2537–2550. doi: 10.1002/jcsm.13050

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© 2022 The Authors. Journal of Cachexia, Sarcopenia and Muscle published by John Wiley & Sons Ltd on behalf of Society on Sarcopenia, Cachexia and Wasting Disorders.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Skeletal muscle fibre composition, fibre size, oxidative capacity, mitochondrial OXPHOS protein levels, capillarity and mitochondrial signalling did not respond to exercise training in MS. Vastus lateralis biopsies were obtained from patients with MS before (pre, blue) and after (post, red) a 12 week exercise training intervention. No significant differences were observed in (A) SDH activity weighted for muscle fibre type, (B) mitochondrial OXPHOS protein levels (complex [C.] I to V), (C) fibre cross‐sectional area (FCSA) for type I, IIa and IIa/x fibres, (D) fibre type composition, (E) capillary density, (F) PGC‐1α protein content, and (G) mRNA expression of various mitochondrial transcription factors and genes.