Table 3.
The overall mortality of all participants who did not use significant amounts of alcohol stratified by BMI category and handgrip strength
| Deaths per 1000 person‐years | Adjusted HR (95% CI) | ||||||
|---|---|---|---|---|---|---|---|
| Total population (n = 12 731) | NAFLD (n = 7083) | Non‐NAFLD (5648) | Multivariable model | P value | Full model | P value | |
| Men (n = 5070) | |||||||
| BMI ≥ 25 kg/m2 (n = 1617) | |||||||
| Quartile 4 (>40 kg) | 4.09 | 4.58 | 2.15 | Reference | Reference | ||
| Quartile 3 (35–40 kg) | 9.14 | 10.4 | 4.39 | 2.66 (1.47–4.84) | 0.003 | 2.65 (1.46–4.81) | 0.003 |
| Quartile 2 (28–34.9 kg) | 18.2 | 19.7 | 12.5 | 3.01 (1.10–8.28) | 0.035 | 2.97 (1.08–8.18) | 0.037 |
| Quartile 1 (<28 kg) | 45.4 | 48.0 | 38.3 | 5.68 (2.26–14.3) | 0.001 | 5.50 (2.23–13.6) | 0.001 |
| BMI 23–24.9 kg/m2 (n = 1104) | |||||||
| Quartile 4 (>40 kg) | 3.69 | 3.91 | 3.50 | 1.62 (0.39–6.62) | 0.486 | 1.53 (0.38–6.21) | 0.536 |
| Quartile 3 (35–40 kg) | 11.4 | 13.0 | 9.76 | 4.15 (1.72–10.0) | 0.003 | 3.96 (1.69–9.31) | 0.003 |
| Quartile 2 (28–34.9 kg) | 16.4 | 21.8 | 11.0 | 3.32 (1.89–5.85) | <0.001 | 3.12 (1.76–5.51) | <0.001 |
| Quartile 1 (<28 kg) | 39.2 | 41.8 | 36.8 | 4.32 (1.82–10.3) | 0.002 | 4.03 (1.73–9.38) | 0.003 |
| BMI < 23 kg/m2 (n = 2349) | |||||||
| Quartile 4 (>40 kg) | 2.68 | 9.74 | 2.04 | 0.98 (0.31–3.12) | 0.966 | 0.85 (0.27–2.75) | 0.785 |
| Quartile 3 (35–40 kg) | 8.94 | 10.4 | 8.73 | 3.33 (1.37–8.13) | 0.011 | 2.97 (1.23–7.16) | 0.018 |
| Quartile 2 (28–34.9 kg) | 19.7 | 23.7 | 19.0 | 3.84 (1.72–8.57) | 0.002 | 3.40 (1.56–7.40) | 0.004 |
| Quartile 1 (<28 kg) | 45.1 | 46.1 | 44.9 | 6.60 (2.50–17.4) | 0.001 | 5.80 (2.30–14.6) | 0.001 |
| Women (n = 7661) | |||||||
| BMI ≥ 25 kg/m2 (n = 3547) | |||||||
| Quartile 4 (>27 kg) | 2.38 | 2.22 | 3.31 | Reference | Reference | ||
| Quartile 3 (23.1–27 kg) | 5.46 | 5.93 | 3.00 | 0.80 (0.41–1.52) | 0.463 | 0.78 (0.40–1.53) | 0.449 |
| Quartile 2 (18–23 kg) | 11.7 | 12.4 | 6.73 | 1.54 (0.90–2.64) | 0.108 | 1.50 (0.85–2.65) | 0.151 |
| Quartile 1 (<18 kg) | 22.8 | 24.1 | 11.1 | 1.81 (0.93–3.53) | 0.079 | 1.72 (0.85–3.51) | 0.125 |
| BMI 23–24.9 kg/m2 (n = 1443) | |||||||
| Quartile 4 (>27 kg) | 2.45 | 3.54 | 1.38 | 1.08 (0.35–3.27) | 0.891 | 1.01 (0.33–3.10) | 0.981 |
| Quartile 3 (23.1–27 kg) | 5.63 | 7.39 | 2.98 | 2.41 (0.81–7.12) | 0.107 | 2.28 (0.71–7.33) | 0.157 |
| Quartile 2 (18–23 kg) | 10.0 | 12.3 | 5.76 | 0.88 (0.46–1.68) | 0.686 | 0.84 (0.42–1.67) | 0.598 |
| Quartile 1 (<18 kg) | 24.6 | 25.8 | 20.6 | 1.59 (0.99–2.54) | 0.051 | 1.46 (0.84–2.55) | 0.166 |
| BMI < 23 kg/m2 (n = 2671) | |||||||
| Quartile 4 (>27 kg) | 2.28 | 1.02 | 2.65 | 1.44 (0.52–3.96) | 0.465 | 1.28 (0.47–3.48) | 0.617 |
| Quartile 3 (23.1–27 kg) | 3.98 | 7.77 | 2.36 | 1.57 (0.83–2.98) | 0.159 | 1.42 (0.69–2.93) | 0.328 |
| Quartile 2 (18–23 kg) | 13.7 | 19.6 | 10.3 | 2.31 (1.21–4.40) | 0.014 | 2.04 (0.90–4.62) | 0.086 |
| Quartile 1 (<18 kg) | 32.5 | 31.5 | 33.3 | 2.87 (1.51–5.46) | 0.003 | 2.55 (1.17–5.55) | 0.021 |
BMI, body mass index; HR, hazards ratio.
The multivariable model was adjusted for age, current smoking, alcohol intake, high‐leisure‐time physical activity, Charlson comorbidity index, and hyperglycaemia/diabetes. The full multivariable model was Model 1 plus an adjustment for NAFLD.